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Bari ( BAR-ee, Italian: [ˈbaːri]; Barese: Bare [ˈbæːrə]; Latin: Barium; Ancient Greek: Βάριον, romanized: Bárion) is the capital city of the Metropolitan City of Bari and of the Apulia region, on the Adriatic Sea, in southern Italy. It is the second most important economic centre of mainland Southern Italy after Naples (and the third after Palermo, if Insular Italy is included), a port and university city, as well as the city of Saint Nicholas. The city itself has a population of 320,257 inhabitants, over 116 square kilometres (45 sq mi), while the urban area has 750,000 inhabitants. The metropolitan area has 1.3 million inhabitants. Bari is made up of four different urban sections. To the north is the closely built old town on the peninsula between two modern harbours, with the Basilica of Saint Nicholas, the Cathedral of San Sabino (1035–1171) and the Hohenstaufen Castle built for Frederick II, which is now also a major nightlife district.